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A growing body of evidence positions Alzheimer's disease as fundamentally a disorder of impaired brain energy metabolism, one in which neurons progressively lose the ability to utilize glucose efficiently, creating an energetic crisis that precedes structural damage by years or even decades

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Pfeffer MA, Claggett B, Diaz R, et al

It is proposed that Ex-4 acts to counteract potassium outflow, thereby delaying repolarization and increasing Ca 2 influx, which in turn enhances insulin secretion [27]

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